Pig-Cox

Each 1 ml of suspension contains:

• Toltrazuril ............ 50 mg
• Solvent to 1 ml
  (Sodium benzoate - E211: 2.1 mg; Sodium propionate - E281: 2.1 mg; Sodium docusate; Simethicone emulsion; Bentonite; Citric acid anhydrous; Xanthan gum; Propylene glycol; Distilled water)

Prevention and treatment of coccidiosis in piglets and calves.

Toltrazuril is a new-generation, broad-spectrum anticoccidial drug. It damages all intracellular developmental stages of Eimeria.

• Toltrazuril affects schizonts, microgametes (male gametes), and macrogametes (female gametes) but does not harm the host’s tissue cells.
• It disrupts nuclear division and mitochondrial activity, inhibiting the respiratory processes of coccidia. In macrogametes, it damages cell wall formation.
• During intracellular development, Toltrazuril induces vacuoles by swelling the endoplasmic reticulum of Eimeria.

After oral administration, Toltrazuril is absorbed slowly from the intestines, with bioavailability >70%. Its metabolites are toltrazuril sulfone and toltrazuril sulfoxide. The elimination half-life is 3 days, and the drug is excreted primarily through feces.

• Piglets: Administer a single dose of 0.4 ml/kg body weight (equivalent to 1 ml per piglet aged 3–5 days or 20 mg Toltrazuril/kg body weight).
• Calves: Administer a single dose of 3 ml/10 kg body weight at 5 weeks of age.

Note: Shake well before use.

OVERDOSE:
The drug is well-tolerated even at 3–5 times the recommended dose.

WITHDRAWAL PERIOD:

For meat consumption:

• Piglets: 70 days
• Calves: 63 days

No known interactions. For instance, no issues were reported when used simultaneously with iron supplements.

None.

None reported.

2 years from the manufacturing date.

Store in a cool, dry place at temperatures below 30°C. Avoid direct sunlight.